People

Principal Investigator

Phone: (415) 476-1291

Fax: (415) 502-5081

email:  aweiss@medicine.ucsf.edu

Arthur Weiss, M.D., Ph.D.

Investigator, Howard Hughes Medical Institute
Ephraim P. Engleman Distinguished Professor
Department of Medicine, Division of Rheumatology
Department of Microbiology and Immunology

Primary Research Interest:  Immunology
Secondary Interest:  Cancer Biology & Cell Signaling
Signal transduction in lymphocytes

 

Research Summary:

Signal transduction in lymphocytes

Receptors involved in antigen recognition functionally interact with tyrosine kinases and phosphatases, enzymes that regulate protein phosphorylation, to induce signaling pathways that regulate cellular responses and gene expression.  We are using genetically selective small molecule inhibitors of kinases together with phosphatase mutants to study how thresholds for the initiation of immune responses are set and how feedback circuits influence responses.  Our goal is to understand how the tyrosine kinases and phosphatases in these pathways are regulated and how they control cellular responses in development, in normal immune responses and in autoimmune diseases such as lupus and rheumatoid arthritis.