ART WEISS LAB

SELECTED RECENT PEER REVIEWED PUBLICATIONS:

2023

• Lo, W.-L., Kuhlmann, M., Rizzuto, G., Atakan Ekiz, A.H., Kolawole, E.M., Revelo, M.P., Andargachew, R., Li, Z., Tsai, Y.-L., Marson, A., Evavold, B.D., Zehn, D., Weiss. A. A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function. Nat. Immunol. 2023 Mar 13. DOI: 101038/s41590-023-01444-x. PMID: 36914891. Online ahead of print.
• Horkova, V. Drobek, A., Paprckova, D., Niederlova, V., Prasai, A. Uleri, V., Glatzova, D., Kraller, M., Kadlecek, T.A., Krizova, K., Platzer, R., Schober, K., Busch, D.H., Weiss, A., Huppa, J.B., Stepanek, O.  Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells.  Nat. Immunol.  2023 Jan 24 (1) 174-185.  https://doi.org/10.1038/s41590-022-01366-0. PMID: 36564464. PMCID: PMC9810533.
• Lu, W., Helou, Y.A., Shrinivinas, K., Liou, J., Au-Yeung, B.B., Weiss, A.  The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P₂ replenishment in response to TCR signaling during T cell development and survival.  Nat. Immunol.  2023.  24: Jan 24; (1)136-147.  https://doi.org/10.1038/s41590-022-01372-2. PMID: 36581712. PMCID:PMC9810531.

2021

• Ashouri J.F., Lo, W.-L., Nguyen T.T.T., Shen, L., Weiss, A.  ZAP 70, too little, too much can lead to autoimmunity. Immunol. Rev. 2021, Dec. 18. doi: 10.1111/imr.13058. Online ahead of print. PMID: 34923645.
• Lu, W., Skrzypczynska, K.M., Weiss, A. Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway. PNAS. 2021. Oct 26:118(43):e2108957118. doi: 10.1073/pnas.2108957118. PMID: 34675079.
• Shen, L., Matloubian, M., Kadlecek, T.A., Weiss. A. A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands. Sci. Signal. 2021. Feb 2;14(668):eabc4479. doi: 10.1126/scisignal.abc4479. PMID: 33531381.
• Lo, W.-L., Weiss, A. Adapting T cell receptor ligand discrimination capability via LAT. Front. Immunol. 2021. Apr 16;12:673196. doi: 10.3389/fimmu.2021.673196. eCollection 2021. PMID: 33936119. PMCID: PMC8085316.
• Hallumi, E., Shalah, R., Lo, W.-L., Corso, J., Ilana, O., Beach, D., Wittman, S., Isenberg, A., Sela, M., Urlaub, H., Weiss, A., Yablonski, D. Itk promotes the integration of TCR and CD28 costimulation through its direct substrates SLP-76 and Gads. J. Immunol. 2021. May 15;206(10):2322-2337. doi: 10.4049/jimmunol.2001053. Epub 2021 Apr. 30. PMID: 33931484. PMCID: PMC8113088 (available on 2022-05-15).
• Nguyen, T.T., Wang, Z.-E., Shen, L., Schroeder, A., Eckalbar, W., Weiss, A. Cbl-b deficiency prevents functional but no phenotypic T cell anergy. J. Exp. Med. 2021. Jul 5;218(7).e20202477. doi: 10.1084/jem.20202477. Epub 2021 May 11. PMID: 33974042.

2020

• Ganti, R.S., Lo, W.-L., McAffee, D.B., Groves, J.T., Weiss A., Chakraborty, A.K. How the T cell signaling network processes information to discriminate between self and agonist ligands. Proc. Natl. Acad. Sci. USA. 2020 Oct5;202008303. DOI: 10.1073/pnas.2008303117. PMID: 33020303. Online ahead of print.

2019

• Courtney, A.H., Shvets, A.A., Lu, W. Griffante, G., Mollenauer, M., Horkova, V., Lo, W.-L., Yu, S., Stepanek, O., Chakraborty, A.K., Weiss, A. CD45 functions as a signaling gatekeeper in T cells. Sci. Signal. 2019 Oct 22;12(604). pii: eaaw8151. doi: 10.1126/scisignal.aaw8151. PMID: 31641081.
• Lo, W._L., Shah, N.H., Rubin, S.A., Zhang, W., Horkova, V., Fallahee, I.R., Stepanek, O., Zon, L.I., Kuriyan, J., Weiss, A. Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. Nat. Immunol. 2019 Nov 20;(11)1481-1493. doi: 10.1038/s41590-019-0502-2. Epub 2019 Oct 14. PMID: 31611699.
• Ashouri, J.F., Hsu, L.Y., Yu, S., Rychkov, D., Chen, Y. Cheng, D.A., Sirota, M., Hansen, E., Lattanza, L., Zikherman, J., Weiss, A. Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. Proc. Natl. Acad. Sci. USA. 2019 Sep 10;116(37):18517-18527. Doi: 10.1073/pnas.1904271116. Epub 2019 Aug 27. PMID: 31455730.
• Zinzow-Kramer, W.M., Weiss, A., Au-Yeung, B.B. Adaptation by naïve CD4+ T cells to self-antigen-dependent TCR signaling induces functional heterogeneity and tolerance. Proc. Natl. Acad. Sci. USA. 2019 Jul 8. pii: 201904096. doi: 10.1073/pnas.1904096116. [Epub ahead of print].
• Chung, J.K., Nocka, L.M., Decker, A., Wang, Q., Kadlecek, T.A., Weiss, A. Kuriyan, J., Goves, J.T. Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization. Proc. Natl. Acad. Sci. USA. 2019 May 28;116(22):10798-10803. Doi: 10.1073/pnas.1819309116. Epub 2019 May 10. PMID: 31076553.
• Wang, Y., Huynh, W., Skokan, T.D., Lu, W., Weiss, A., Vale, R.D. CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic. J. Cell Biol. Feb 27, 2019. Doi: 10.1083/jcb.201806097. [Epub ahead of print]. PMID: 30814157.

2018

• Nagy, Z., Vogtle, T., Geer, M.J., Mori, J., Heising, S., Di Nunzio, G., Gareus, R., Tarakhovsky, A., Weiss, A., Neel, B.G., Desanti, G.E., Mazharian, A., Senis, Y.A.  The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions. Blood. Nov 14, 2018. doi: 10.1182/blood-2018-09-877787. [Epub ahead of print]. PMID: 30429161.
• Lo, W.L., Shah, N.H, Ahsan, N., Horkova V., Stepanek, O., Salomon, A.R., Kuriyan, J., Weiss, A. Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT. Nat Immunol. 2018. Jun 18. doi: 10.1038/s41590-018-0131-1. [Epub ahead of print]. PMID: 29915297.
• Shang, W., Jiang, Y., Boettcher, M., Ding, K., Mollenauer, M., Liu, Z., Wen, X., Liu, C., Hao, P., Zhao, S., McManus, M.T., Wei, L., Weiss, A., Wang, H.  Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation.  Proc. Natl. Acad. Sci. USA.  2018. Apr 24;115(17):E4051-E4060. Epub 2018 Apr 9. PMID: 29632189. PMCID: PMC5924929.
• Shah, N.H., Lobel, M., Weiss, A., Kuriyan, J.  Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen.  Elife. 2018. Mar 16;7. pii: e35190. doi: 10.7554/eLife.35190. [Epub ahead of print]. PMID: 29547119. PMCID: PMC5889215.
• Mori, J., Nagy, Z., Di Nunzio, G., Smith, C.W., Geer, M.J., A.I. Ghaithi, R., van Geffen, J.P., Heising, S., Boothman, L., Tullemans, B.M.E., Correia, J.N., Tee, L., Kuijpers, M.J.E., Harrison, P., Heemskerk, J.W.M., Javis, G.E., Tarakhovsky, A., Weiss, A., Mazharian, A., Senis, Y.A.  Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.  Blood. 2018. Mar. 8;131(10):1122-1144. doi: 10.1182/blood-2017-02-768077. Epub 2018 Jan 4. PMID: 29301754. PMCID: PMC5888341.

2017

• Smith, G.A., Taunton, J., Weiss, A.  IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells.  Sci. Signal. 2017. Dec. 19;10(510). pii: eaan4931. doi: 10.1126/scisignal.aan4931. PMID: 29259099. PMCID: PMC5741096 [Available on 2018-06-19].
• Courtney, A.H., Lo, W.-L., Weiss, A.  TCR Signaling: Mechanisms of initiation and propagation.  Trends Biochem. Sci. 2017. Dec. 18; pii: S0968-0004(17)30221-9;  doi: 10.1016/j.tibs.2017.11.008. [Epub ahead of print]. PMID: 29269020. PMCID: PMC5801066. [Available on 2018-06-19]. 
• Au-Yeung, B.B., Shah, N.H., Shen, L., Weiss, A.  ZAP-70 in Signaling, Biology, and Disease.  Annu. Rev. Immunol. Dec 13, 2017; doi: 10.1146/annurev-immunol-042617-053335. [Epub ahead of print]. PMID: 29237129.
• Courtney, A.H., Amacher, J.F., Kadlecek, T.A., Mollenauer, M.N., Au-Yeung, B.B., Kuriyan, J., Weiss, A.  A phosphosite within the SH2 domain of LcK regulates its activation by CD45.  Mol Cell. 2017 Jul 11; pii: S1097-2765(17)30458-6. doi: 10.1016/j.molcel.2107.06.024. [Epub ahead of print]. PMID: 28735895. PMCID: PMC5558854. [Available on 2018-08-03].
• Au-Yeung, B.B., Smith, G.A., Mueller, J.L., Heyn, C.S., Jaszczak, R.G., Weiss, A., Zikherman, J.  IL-2 modulates the TCR signaling threshold for CD8 but not CD4 T cell proliferation on a single-cell level.  J Immunol. 2017 Feb 3. pii:  1601453. doi: 10.4049/jimmunol.1601453. [Epub ahead of print]. PMID: 28159902. PMCID: PMC5340617.
• Hsu, L.Y., Cheng, D.A., Chen, Y., Liang, H.E., Weiss, A. Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness.  J. Exp. Med. 2017 Feb 3. pii: jem.20161575. doi: 10.1084/jem20161575. [Epub ahead of print]. PMID: 28159798. PMCID: PMC5339679.

2016

• Ashouri, J.F., Weiss, A.  Endogenous Nur77 is a specific indicator of antigen receptor signaling in human T and B cells.  J Immunol. 2016 Dec 9. pii: 1601301. [Epub ahead of print]  PMID: 27940659. PMCID: PMC5224971.
• Visperas, P.R., Wilson, C.G., Winger, J.A., Yan, Q, Lin, K., Arkin, M.R., Weiss, A., Kuriyan, J.  Identification of inhibitors of the association of ZAP-70 with the T cell receptor by high-throughput screen.  J. Biomol. Screen.  2016.  Dec 8.  pii:  1087057116681407. [Epub ahead of print]  PMID: 27932698. PMCID: PMC5491343.
• Skrzypczynska, K.M., Zhu, J.W., Weiss, A.  Positive regulation of Lyn kinase by CD148 is required for B cell receptor signaling in B1 but not B2 B cells.  Immunity.  2016.  Nov 15.  pii: S1074-7613(16)30424-1. doi:  10.1016/j.immuni.2016.10.013. [epub ahead of print]  PMID: 27889108.
• Shah, N.H., Wang, Q., Yan, Q., Karandur, D., Kadlecek, T.A., Fallahee I.R., Russ, W.P., Ranganathan, R., Weiss, A., Kuriyan, J.  An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. Elife. 2016. Oct 4;5. pii: e20105. doi: 10.7554/eLife.20105. PMID: 27700984. PMCID: PMC5089863.
• Thill, P.A., Weiss, A., Chakraborty, A.K. Phosphorylation of a Tyrosine residue on Zap70 by Lck and its subsequent binding via a SH2 domain may be a key gatekeeper of T cell receptor signaling in vivo. Mol. Cell. Biol. 2016 Jun 27. pii:MCB.00165. [Epub ahead of print] PMID: 27354065. PMCID: PMC5007795.
• Esensten, J.H., Helou, Y.A., Chopra, G., Weiss, A., Bluestone, J.A. CD28 costimulation: From mechanism to therapy. Immunity. 2016 May 17;44(5):973-88. doi: 10.1016/j.immuni.2016.04.020. Review. PMID: 27192564. PMCID: PMC4932896.
• Smith, G.A., Uchida, K., Weiss, A., Taunton, J. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol. 2016 May;12(5):373-9. doi: 10.1038/nchembio.2056. Epub 2016 Mar 28. PMID: 27018889, PMCID: PMC4837022.
• Chi, S., Weiss, A., Wang, H.  A CRISPR-based toolbox for studying T cell signal transduction.  BioMed Research International.  2016. Volume 2016, article ID 5052369, http://dx.doi.org/10. Epub 2016 Feb 1. 1155/2016/5052369. PMID: 27057542, PMCID: PMC4753324.
• Chan, A.Y., Punwani, D., Kadlecek, T.A., Cowan, M.J., Olson, J.L., Mathes, E.F., Sunderam, U., Shu Man Fu, Srinivasan, R., Kuriyan, J., Brenner, S.E., Weiss, A., Puck, J.M. A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70. 2016  J. Exp. Med. Published online January 18, 2016.10.1084/jem.20150888. PMID: 26783323. PMCID: PMC4749924.

2015

• Coughlin, S., Noviski, M., Mueller, J.L., Chuwonpad, A., Raschke, W,C., Weiss, A., Zikherman, J.  An extra-catalytic function of CD45 in B cells is mediated by CD22.  Proc. Natl. Acad. Sci. USA. 2015 Nov 24;112(47):E6515-24. doi: 10.1073/pnas.1519925112. Epub 2015 Nov 11.  PMID:  26561584.  PMCID: PMC4664364.
• Freedman, T.S., Tan, Y.X., Skrzypczynska, K.M., Manz, B.N., Sjaastad, F.V., Goodridge, H.S., Lowell, C.A., Weiss. A.  LynA regulates an inflammation-sensitive checkpoint in macrophages.  Elife 2015 0ct 30;4. pii: e09183. doi: 10.7554/eLife.09183. PMID: 26517880.
• Manz, B.N., Tan, Y.X., Courtney, A.H., Rutaganira, F., Palmer, E., Shokat, K.M., Weiss, A.  Small molecule inhibition of Csk alters affinity recognition by T cells.  eLife. 2015; 4: e08088.  Published online 2015 August 24. dol: 10.7554/eLife.08088. PMCID. PMC4568592.
• Tian, R., Wang, H., Gish, G.D., Petsalaki, E., Pasculescu, A., Shi, Y., Mollenauer, M., Bagshaw, R.D., Yosef, N., Hunter, T., Gingras, A.-C., Weiss, A., Pawson, T.  Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor. Proc. Natl. Acad. Sci. USA. March 31, 2015;112(13):E1594-603. doi: 10.1073/pnas.1503286112. Epub 2015 Mar 17.  PMID:  25829543.
• Visperas, P.R., Winger, J.A., Horton, T.M., Shah, N.H., Aum, D.J., Tao, A., Barros, T., Yan, Q., Wilson, C.G., Arkin, M.R., Weiss, A., and Kuriyan, J.  Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.  Biochemical J. 2015 Jan 1;465(1):149-61.PMID: 25287889, PMCID: PMC4410814.
• Mills, R.E., Lam, V.C., Tan, A., Cresalia, N., Oksenberg, N., Zikherman, J., Anderson, M., Weiss, A., Hermiston, M.L. Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production.  J. Immunol. March 13, 2015. pii:  1500026. [Epub ahead of print]  PMID:  25769918
• Punwani, D., Wang, H., Chan, A.Y., Cowan, M.J., Mallott, J., Sunderam, U., Mollenauer, M., Srinivasan, R., Brenner, S.E., Mulder, A., Claas, F.H., Weiss, A., Puck, J.M.  Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation.  J Clin Immunol. 2015 Feb;35(2):135-46. doi: 10.1007/s10875-014-0125-1. Epub 2015 Jan 28.  PMID: 25627829.  PMCID: PMC4352191.
• Chen, Z., Shojaee, S., Buchner, M., Geng, H., Lee, J.W., Klemm, L., Titz, B., Graeber, T.G., Park, E., Tan, Y.X., Satterthwaite, A., Paietta, E., Hunger, S.P., Willman, C.L., Melnick, A., Loh, M.L., Jung, J.U., Coligan, J.E., Bolland, S., Mak, T.W., Limnander, A., Jumaa, H., Reth, M., Weiss, A., Lowell, C.A., Müschen, M. Signaling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.  Nature. 2015 Mar 23. doi: 10.1038/nature14231. [Epub ahead of print].  PMID 25799995.
• Sjölin-Goodfellow H, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon AR, Weiss A.  The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.  Sci Signal. 2015 May 19;8(377):ra49. doi: 10.1126/scisignal.2005596. PMID 25990959.  PMCID: PMC444542.
• Weiss A, Stobo JD.  Commentary: “The role of T3 surface molecules in the activation of human cells: A two-stimulus requirement for IL-2 production reflects events occurring at a pretranslational level. Front Immunol. 2015 Apr 21;6:163. doi:10.3389/fimmu.2015.00163. eCollection 2015. PMID 25954271.

2014

• Jenkins, M.R., Stinchcombe, J.C., Ritter, A.T., Au-Yeung, B.B., Weiss, A., and Griffiths, G.M.  Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.  Elife., 2014 Jan 1;3:e01310. doi: 10.7554/eLife.01310.  PMCID: PMC3936284.
• Tan, Y.-X., Manz, B.N., Freedman, T.S., Zhang, C., Shokat, K.M., and Weiss, A.  Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.  Nat. Immunol., 2014 Feb;15(2):393-401. PMCID: PMC3946925.
• Limnander, A., Zikherman, J., Lau, T., Leitges, M., Weiss, A., and Roose, J.P. Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Mol. Cell. Biol., 2014 Apr;34(8):1474-85.  PMCID: PMC3993585.
• Wang, H., Flach, H., Onizawa, M., Wei, L., McManus, M.T., and Weiss, A.  Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia regulated microRNA miR-210.  Nature Immunol., Apr;15(4):393-401. doi: 10.1038/ni.2846. PMCID: PMC3996831.
• Phee, H., Au-Yeung, B., Pryshchep, O., O'Hagan, K., Fairbairn, S., Radu, M., Kosoff, R., Mollenauer, M., Cheng, D., Chernoff, J., and Weiss, A.  Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.  Elife 2014 May 13;3:e02270.  DOI: 10.7554/eLife.02270.
• Au-Yeung,  B.B., Melichar, H.J., Ross, J.O., Cheng, D.A., Zikherman, J., Shokat, K.M., Robey, E.A., and Weiss, A.  Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.  Nat. Immunol.  2014 15:687-694.  PMCID: PMC24908390.
• Ross, J.O., Melichar, H.J., Au-Yeung, B.B., Herzmark, P., Weiss, A., and Robey, E.A.  Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T cell receptor signaling patterns.  Proc. Natl. Acad. Sci. USA. 2014 Jun 24; 111:E2550-2558.   PMCID: PMC4078834.
• Schim van der Loeff, I., Hsu, L.Y., Saini, M., Weiss, A., and Seddon, B.  Zap70 is essential for long-term survival of naive CD8 T cells.  J. Immunol. 2014.  Sep 15;193(6):2873-80.  PMCID: PMC4167606.
• Au-Yeung, B.B., Zikherman, J., Mueller, J.L., Ashouri, J.F., Matloubian, M., Cheng, D.A., Chen, Y., Shokat, K.M., and Weiss, A.  A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.  Proc. Natl. Acad. Sci. USA.  2014  Aug 18.  pii: 201413726. PMCID: PMC4156735.
• Chakraborty, A.K., and Weiss, A.  Insights into the initiation of TCR signaling.  Nat. Immunol.,  2014  Aug 19; 15(9):798-807.  doi: 10. 1038/ni2940.  PMID:  25137454.

2013

• Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS.  Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4+ cells.  Immunity. Sep 19;39(3):560-72, 2013.
• Zhang B, Zhou Y, Lin N, Lowdon RF, Hong C, Nagarajan RP, Cheng JB, Li D, Stevens M, Lee HJ, Xing X, Zhou J, Sundaram V, Elliott G, Gu J, Shi T, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Maire CL, Ligon KL, Madden PA, Tam A, Moore R, Hirst M, Marra MA, Zhang B, Costello JF, Wang T.  Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm.  Genome Res. Sep;23(9):1522-40, 2013.  PMCID: PMC3759728.
• Xie, M., Hong, C., Zhang, B., Lowdon, R., Xing, X., Li, D., Zhou, X., Lee H.J., Maire C.L., Ligon, K.L., Gascard, P., Sigaroudinia, M., Tlsty, T.D., Kadlecek, T., Weiss, A., O’Geen, H., Farnham, P.J., Madden P.A.F., Mungall, A.J., Tam, A., Kamoh, B., Cho, S., Moore, R., Hirst, M., Marra, M.A., Costello, J.F., Wang T. DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nature GeneticsJul;45(7):836-41, 2013.  PMCID: PMC3695047.
• Katsumoto, T.R., Kudo, M, Chen, C., Sundaram, A., Callahan, E., Zhu, J., Lin, J., Rosen, C.E., Manz, B., Lee, J.W., Matthay, M.A., Huang, X., Sheppard, D., and Weiss, A.  The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.  J. Clin. Invest. 1;123(5):2037-48. 2013. PMCID: PMC3635736.
• Yan, Q., Barros, T., Visperas, P.R., Deindl, S., Kadlecek, T.A., Weiss, A., and Kuriyan, J.  Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.  Mol. Cell. Biol. 33(11):2188-201, 2013. PMCID: PMC3648074.
• Zikherman, J., Parameswaran, R., Hermiston, M., and Weiss, A.  The wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.  J. Immunol. 2013 Mar 15;190(6):2527-35, 2013.  PMCID: PMC3593789.
• Mukherjee, S., Zhu, J., Zikherman, J., Parameswaran, R., Kadlecek, T.A., Wang, Q., Au-Yeung, B., Ploegh, H., Kuriyan, J., Das, J.*, and Weiss, A.*  Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.  Sci. Signal.  Jan 1;6(256):ra1, 2013.   *co-corresponding authors.  PMCID: PMC3742096.   

2012

• Charles, J.F., Hsu, L.-H., Niemi, E.C., Weiss, A., Aliprantis, A.O., and Nakamura, M.C.  Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function.  J. Clin. Invest.  122:4592-4605, 2012.  PMCID: PMC3533532.
• Zikherman, J., Parameswaran, R., and Weiss, A.  Endogenous antigen tunes the responsiveness of naive B cells but not T cells.  Nature. 489:160-164, 2012. PMCID: PMC3438375.
• Wei, P., Wong, W.W., Corcoran, E.E., Peisajovich, S.G., Weiss, A., and  Lim, W.A. Bacterial virulence proteins as tools to synthetically rewire kinase pathways in yeast and immune cells.  Nature.  488:384-388.  2012.  PMCID:  PMC3422413.
• Abel, S.M., Roose, J.P., Groves, J.T., Weiss, A., and Chakraborty, A.  The membrane environment can promote or suppress bistability in cell signaling networks.  J. Phys. Chem. B.  116:3630-3640.
• Park C.Y., Jeker L.T., Carver-Moore K., Oh A., Liu H.J., Cameron R., Richards H., Li Z., Adler D., Yoshinaga Y., Martinez M., Nefadov M., Abbas A.K., Weiss A., Lanier L.L., de Jong P.J., Bluestone J.A., Srivastava D., McManus M.T. A Resource for the Conditional Ablation of microRNAs in the Mouse. Cell Reports 1:385-391, 2012.

2011

• Zikherman, J., Doan, K., Parameswaran, R., Raschke, W., and Weiss., A.  Quantitative differences in CD45 expression unmasks functions for CD45 during B-cell development, tolerance and survival.  Proc. Natl. Acad. Sci., USA.  2012 Jan 3;109(1):E3-E12. Epub 2011 Nov 30.
• Draber, P.,  Vonkova, I.,  Stepanek, O.,  Hrdinka, M., Kucova, M., Skopcova, T., Otahal, P., Angelisova, P.,  Horejsi, V., Yeung, M., Weiss, A., Brdicka, T.  SCIMP:  transmembrane adaptor protein involved in MHCII signaling.  Mol. Cell. Biol.  31:4550-4562.  2011.
• Markegard, E., Trager, E., Yang C.O., Zhang, W., Weiss, A, and Roose, J.P.  Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRa gene expression.  PLoS One. 6(9):e25540.  2011.
• Zhu, J.W.,  Doan, K.,  Park, J.,  Chau, A.H., Zhang, H.,  Lowell, C.A., and Weiss, A.  Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus infection.  Immunity.  35:757-769.  2011.
• Schoenborn, J.R., Tan, Y.X., Zhang, C., Shokat, K., and Weiss, A.  Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling.  Sci. Signal.  4(190):ra59
• Stepanek, O., Kalina, T., Draber, P., Skopcova, T., Svojgr, K., Angleisova, P., Horejsi, V., Weiss, A., and Brdicka, T.  Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.  J. Biol. Chem.  286:22101-22112.  2011.
• Goodrich, H.S., Reyes, C.N., Becker, C.A., Katsumoto, T.R., Ma, J., Wolf, A.J., Bose, N., Chan, A.S., Magee, A.S., Danielson, M.E., Weiss, A., Vasilakos, J.P., and Underhill, D.  Activation of the innate immune receptor Dectin-1 upon formation of a "phagocytic synapse".  Nature.  472:471-475.  2011.
• Limnander, A., Depeille, P., Freedman, T.S., Liou, J., Leitges, M., Kurosaki, T., Roose, J.P., and Weiss, A. STIM1, PKC-d and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat. Immunol. 12:425-433. 2011.
• Liontos, L.M., Dissanayake, D., Ohashi, P.S., Weiss, A., Dragone, L.L., and McGlade, C.J. The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation. J. Immunol. 186:1923-1933. 2011.
• Hesslein, D.G., Palacios, E.H., Sun, J.C., Beilke, J.N., Watson, S.R., Weiss, A., and Lanier, L.L. Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases. Blood. 117:3087-3095. 2011.

2010

• Au-Yeung, B.B, Levin, S.E., Zhang, C., Hsu, L.-Y., Cheng, D., Killeen, N., Shokat, K.M., and Weiss. A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat. Immunol. 11:1085-1093. 2010.
• Beinke, S., Phee, H., Clingan, J.M., Schlessinger, J., Matloubian, M., and Weiss, A. Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector cells. Proc. Natl. Acad. Sci. USA 107:16234-16239. 2010
• Phee, H., Dzhagalov, I., Mollenauer, M., Wang, Y., Irvine, D.J., Robey, E., and Weiss, A. Regulation of thymocyte positive selection and motility by GIT2. Nat. Immunol., 11:503-511. 2010.
• Zikherman, J., Jenne, C., Watson, S., Doan, K., Raschke, W., Goodnow, C.C., and Weiss, A. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity, 32:342-354. 2010.

2009

• Deindl, S.*, Kadlecek*, T.A., Cao, X., Kuriyan, J., and Weiss. A. Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response. Proc. Natl. Acad. Sci. USA, 106:20699-20704, 2009. * co-first authors
• Hsu, L.-Y., Tan, Y.X., Xiao, Z., Malissen, M., and Weiss, A. A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J. Exp. Med., 206:2527-2541, 2009
• Xavier, C., Gabay, J.E., Reyes, M., Zhu, J.W., Weiss, A., and Shuman, H.A. Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by legionella pneumophilia. PLoS Path, July 5(7):e1000501, 2009.
• Senis, Y.A., Tomlinson, M.G., Ellison, S., Mazharian, A., Lim, J., Zhao, Y, Kornerup, K.N., Auger, J.M., Thomas, S.G., Dhanjal, T., Kalia, N., Zhu, J.W., Weiss, A. and Watson, S.P. The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood, 113:4942-4954. 2009.
• Zikherman, J., Hermiston, M., Steiner, D., Hasegawa, K., Chan, A. and Weiss, A. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J. Immunol., 182:4093-4106. 2009.
• Grochowy, G., Hermiston, M.L., Kuhny, M., Weiss, A. and Huber, M. Requirement for CD45 in fine-tuning mast cell responses mediated by different ligant-receptor systems. Cell Sig., 8:1277-1286. 2009.
• Das, J., Ho, M., Zikherman, J., Govern, C., Yang, M., Weiss, A., Chakraborty, A.K., and Roose, J.P. Digital signaling and hysteresis characterize Ras activation in lymphoid cells. Cell. 136:337-351 2009.